Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study
Among these nine genes, NR3C1, which encodes a glucocorticoid receptor, is by far the most investigated, being associated with depressive symptoms, early life adversity, and stress. While further research is needed to fully understand the complex relationship between gene expression, life adversities, and psychopathology, our findings provide valuable insights into the molecular mechanisms underlying mental disorders.
Authors
- Julia Schäfer (ORCID: https://orcid.org/0000-0002-5882-6775)
- Helena B. Conceição (ORCID: https://orcid.org/0000-0003-3876-5407)
- Carolina Muniz Carvalho (ORCID: https://orcid.org/0000-0002-3376-9831)
- Amanda Bugiga (ORCID: https://orcid.org/0000-0002-1395-0342)
- Marcos Santoro (ORCID: https://orcid.org/0000-0001-5714-9509)
- Luís Augusto Rohde (ORCID: https://orcid.org/0000-0002-4552-4188)
- Eurı́pedes Constantino Miguel (ORCID: https://orcid.org/0000-0002-9393-3103)
- Vanessa Ota (ORCID: https://orcid.org/0000-0003-0129-6360)
- Rodrigo Grassi‐Oliveira (ORCID: https://orcid.org/0000-0001-9911-5921)
- Maurício Scopel Hoffmann (ORCID: https://orcid.org/0000-0003-4232-3169)
- Gisele Gus Manfro (ORCID: https://orcid.org/0000-0002-0109-7591)
- Pedro A. F. Galante (ORCID: https://orcid.org/0000-0002-4820-4155)
- Síntia Belangero (ORCID: https://orcid.org/0000-0002-2419-4351)
- Giovanni Abrahão Salum (ORCID: https://orcid.org/0000-0002-7537-7289)
- Elisa Brietzke (ORCID: https://orcid.org/0000-0003-2697-1342)
- Ary Gadelha (ORCID: https://orcid.org/0000-0002-0993-8017)
- Paula Fontes Asprino (ORCID: https://orcid.org/0000-0002-2157-5853)
- Rodrigo A. Bressan (ORCID: https://orcid.org/0000-0002-0868-4449)
- Pedro Mário Pan (ORCID: https://orcid.org/0000-0002-1943-6520)
- Adrielle Martins Oliveira
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Aarhus University (DK)
- Queen's University (CA)
- Universidade Federal de Santa Maria (BR)
- Fundação de Apoio à Universidade Federal de São Paulo (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Child Mind Institute (US)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Hospital Sírio-Libanês (BR)
- Universidade Federal de São Paulo (BR)
- London School of Economics and Political Science (GB)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fpsyt.2025.1505421
- Citations
- 4
- Primary Topic
- Resilience and Mental Health
- Type
- article
- Field-Weighted Citation Impact
- 9.23
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Federal do Rio Grande do Sul
- National Institutes of Health