Prevalence of <i>Plasmodium falciparum</i> Drug Resistance Markers <i>pfcrt</i> K76T and <i>pfaat1</i> S258L in Southern Rwanda, 2010 to 2023
The persistence of pfcrt K76T 20 years after abolishing chloroquine use indicates ongoing drug selection or importation. The fixation of pfaat1 S258L argues against a major fitness cost of this variant in Huye. Increases in partial artemisinin resistance in Rwanda and molecular markers indicate compromised lumefantrine efficacy. The observed pfcrt and pfaat1 signatures in the study area might be of use in guiding artemisinin partner drug alternatives.
Authors
- Christian Ngarambe
- Frank P. Mockenhaupt (ORCID: https://orcid.org/0000-0002-8117-5421)
- Jason A. Hendry (ORCID: https://orcid.org/0000-0003-4164-3179)
- Karolina Glanz (ORCID: https://orcid.org/0000-0002-8511-8942)
- Welmoed van Loon (ORCID: https://orcid.org/0000-0003-3331-3997)
- Clement Igiraneza
- Jules Ndoli (ORCID: https://orcid.org/0000-0001-6649-3547)
- Djibril Mbarushimana
- Emma Schallenberg
Institutions
- Max Planck Institute for Infection Biology (DE)
- University of Rwanda (RW)
- Center for Global Health (US)
- University Teaching Hospital of Butare (RW)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1093/infdis/jiaf068
- Citations
- 2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 3.76