The effects of hypothalamic microglial activation on ventricular arrhythmias in stress cardiomyopathy
SCM was induced in SD rats by immobilization stress, acting through the activation of the hypothalamic microglia. The activated microglia were specifically enriched in the PVN, increasing the activity of the central and peripheral sympathetic nervous systems by regulating the expression of neuro-inflammatory factors, mediating dysfunction of the left ventricle, and increasing the susceptibility to ventricular arrhythmias.
Authors
- Kausar Abbas Saldera
- Dechun Yin
- Quanwei Pei
- Dezhan Su
- Junpei Zhang (ORCID: https://orcid.org/0000-0002-8398-306X)
- Pengqi Lin
- Hongpeng Yin
- Zhaolei Jiang (ORCID: https://orcid.org/0000-0002-5206-0852)
- Nevzorova Vera A
- Bin Li (ORCID: https://orcid.org/0000-0002-2082-4571)
- Jingjie Li (ORCID: https://orcid.org/0000-0001-6569-9578)
- Junjie Yang (ORCID: https://orcid.org/0000-0002-6822-6423)
- Lina Zou (ORCID: https://orcid.org/0009-0009-5824-3738)
- Jiemei Yang
- Mbabazi Nadine
Institutions
- Harbin Medical University (CN)
- Vladivostok State Medical University (RU)
- XinHua Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Geriatric Cardiology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.26599/1671-5411.2024.12.002
- Primary Topic
- Takotsubo Cardiomyopathy and Associated Phenomena
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harbin Medical University
- National Natural Science Foundation of China