T1-relaxation times along the corticospinal tract as a diagnostic marker in patients with amyotrophic lateral sclerosis
T1-relaxation times along the corticospinal tract are significantly elevated in ALS patients compared to CG and associated with lower ALSFRS-R. These results imply the analysis of T1-relaxation times as a promising diagnostic tool that can distinguish ALS patients from the control group. Ongoing longitudinal studies may provide deeper insights into disease progression and the effects of therapeutic interventions.
Authors
- Mathias Bähr (ORCID: https://orcid.org/0000-0002-9570-1592)
- Jan Liman (ORCID: https://orcid.org/0000-0002-7465-9655)
- Ilko Maier (ORCID: https://orcid.org/0000-0001-6988-8878)
- Sabine Hofer (ORCID: https://orcid.org/0000-0003-4986-3539)
- Jan Albrecht (ORCID: https://orcid.org/0000-0001-6063-6228)
- Amélie Carolina Hesse
- Jan Christoph Koch (ORCID: https://orcid.org/0000-0002-3778-0683)
- Jens Frahm (ORCID: https://orcid.org/0000-0002-8279-884X)
- Fiona Dierksen (ORCID: https://orcid.org/0009-0004-1913-0603)
- Peter Dechent (ORCID: https://orcid.org/0009-0006-4005-3352)
- Johanna S Geibel
Institutions
- Max Planck Institute for the Study of Religious and Ethnic Diversity (DE)
- Nuremberg Hospital (DE)
- Universitätsmedizin Göttingen (DE)
- Max Planck Institute for Multidisciplinary Sciences (DE)
Publication Details
- Journal
- Frontiers in Neuroimaging
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fnimg.2025.1549727
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Gesellschaft für Muskelkranke