Immune profiling of the macroenvironment in colorectal cancer unveils systemic dysfunction and plasticity of immune cells
Distinct immunotypes are identified in the CRC macroenvironment. TLS and immunotherapy exert influence on the immune macroenvironment. TLS presence correlates with patient survival, CMS and therapeutic efficacy of ICI. PD-1 and CD69 expressed in CD8+ Tem from blood can predict TLS presence in the CRC macroenvironment.
Authors
- Haoxian Ke (ORCID: https://orcid.org/0000-0003-0837-8174)
- Shubiao Ye (ORCID: https://orcid.org/0000-0002-4203-4546)
- Kui Wu (ORCID: https://orcid.org/0000-0002-6857-7231)
- Dongbing Liu (ORCID: https://orcid.org/0000-0003-2870-5187)
- Tuo Hu (ORCID: https://orcid.org/0000-0001-7069-1466)
- Xinlan Zhou (ORCID: https://orcid.org/0000-0001-9293-0894)
- Junfeng Huang (ORCID: https://orcid.org/0000-0002-1672-3751)
- Peisi Li
- Xianrui Wu (ORCID: https://orcid.org/0000-0002-4743-7133)
- Xian Zeng (ORCID: https://orcid.org/0000-0001-5875-3599)
- Ming Yuan (ORCID: https://orcid.org/0000-0003-2935-3320)
- Zhonghui Tang (ORCID: https://orcid.org/0000-0003-2907-3986)
- Chi Zhang (ORCID: https://orcid.org/0000-0002-2341-3129)
- Shaopeng Chen (ORCID: https://orcid.org/0000-0002-3632-9727)
- Runfeng Yu
- Ping Lan (ORCID: https://orcid.org/0000-0002-5225-5027)
- Xiaofang Chen (ORCID: https://orcid.org/0009-0005-4945-2539)
- Shichen Dong
- Shuzhen Luo
- Z. Y. Li (ORCID: https://orcid.org/0000-0003-3465-7994)
Institutions
- BGI Group (China) (CN)
- Sun Yat-sen University (CN)
- Chinese Academy of Sciences (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- BGI Genomics
- BGI Research (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/ctm2.70175
- Citations
- 21
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 21.95
Funders
- National Key Research and Development Program of China