Multi-parametric [18F]PI-2620 tau PET/MRI for the phenotyping of different Alzheimer’s disease variants
This study highlights structural and functional differences between patients with different AD phenotypes. Differences in regional tau PET signals suggest that refinements in the Braak staging system are needed for the non-aAD cases. These patterns of tau accumulation align with the cascading network failure hypothesis, though more research is needed to warrant the here presented results in larger patient cohorts.
Authors
- Norman Koglin (ORCID: https://orcid.org/0000-0001-7583-8201)
- Osama Sabri (ORCID: https://orcid.org/0000-0002-6425-3504)
- Solveig Tiepolt (ORCID: https://orcid.org/0000-0003-0378-8334)
- Michael Rullmann (ORCID: https://orcid.org/0000-0002-2683-9432)
- Dylan Jozef Hendrik Augustinus Henssen (ORCID: https://orcid.org/0000-0002-3915-3034)
- Andrew Stephens (ORCID: https://orcid.org/0000-0001-5052-6586)
- Henryk Barthel (ORCID: https://orcid.org/0000-0002-9322-9167)
- Matthias L. Schroeter (ORCID: https://orcid.org/0000-0001-7977-1083)
- Maria Strauß (ORCID: https://orcid.org/0000-0002-0072-2199)
- Karl-Titus Hoffmann
- Dorothee Saur
- Cordula Scherlach (ORCID: https://orcid.org/0000-0002-8055-6126)
- Andreas Schildan (ORCID: https://orcid.org/0000-0002-9418-3826)
- Swen Hesse (ORCID: https://orcid.org/0000-0002-2055-2764)
- J Melasch
- Joseph Claßen (ORCID: https://orcid.org/0000-0001-7182-6967)
- Matthias Brendel
- Olena Mishchenko
Institutions
- Radboud University Nijmegen (NL)
- German Center for Neurodegenerative Diseases (DE)
- Radboud University Medical Center (NL)
- LMU Klinikum (DE)
- Städtisches Klinikum Dessau (DE)
- Munich Cluster for Systems Neurology (DE)
- University Hospital Leipzig (DE)
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Ludwig-Maximilians-Universität München (DE)
- Leipzig University (DE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1007/s00259-025-07135-z
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Universität Leipzig