AMELIORATIVE EFFECTS OF VITAMIN E ON CARBAMAZEPINE INDUCED HEPATIC TOXICITY IN MALE SPRAGUE DAWLEY RATS

Background: Carbamazepine (CBZ) is prescribed for various neurological and psychiatric disorders. While its therapeutic efficacy is well-established, concerns about hepatotoxicity have arisen due to liver enzyme abnormalities and rare cases of severe liver injury. The aim of this study was to investigates protective effects of Vitamin E against carbamazepine-induced hepatotoxicity via liver enzyme analysis in male Sprague Dawley rats. Methods: Fifty-four male albino Sprague Dawley rats were randomly divided into Groups A, B, and C. Each group was further split into three subgroups of six, based on treatment duration (2, 4, and 6 weeks). Group A served as the control group. Group B received Carbamazepine (50 mg/Kg) via gastric gavage for 2, 4, or 6 weeks. Group C received Vitamin E (200 mg/Kg/day) along with CBZ for the same periods. After the respective treatment durations, the animals were weighed and sacrificed, and blood was collected via cardiac puncture for liver enzyme analysis. Results: Carbamazepine caused hepatotoxicity, evidenced by decreased body weight, increased liver weight, and elevated ALT, ALP, and GGT levels compared to controls. Co-administration of Vitamin E significantly reduced body weight loss, liver weight gain, and the rise in liver enzymes. Conclusion: The findings of this study suggest the potential protective role of Vitamin E against CBZ-induced hepatotoxicity in rat model. Vitamin E may aid in protecting the adverse reactions of CBZ as an adjuvant therapy. Pak J Physiol 2024;20(4):56-9, Doi: https://doi.org/10.69656/pjp.v20i4.1721