Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women
This approach may provide a potential non-animal alternative that could contribute to our understanding of drug behavior during pregnancy and may support early-stage drug safety assessment for vulnerable populations.
Authors
- Katja Graf
- Stephan Schaller (ORCID: https://orcid.org/0000-0003-1046-7651)
- José M. Murrieta-Coxca (ORCID: https://orcid.org/0000-0003-4093-1419)
- Diana M. Morales‐Prieto (ORCID: https://orcid.org/0000-0002-7348-059X)
- Christian Maaß (ORCID: https://orcid.org/0000-0001-7618-0421)
- Tim Kaden (ORCID: https://orcid.org/0000-0003-4976-4434)
- Ramy M. Ammar (ORCID: https://orcid.org/0000-0002-5183-2232)
- Thomas Vogt (ORCID: https://orcid.org/0000-0002-2824-5005)
- Martin Raasch (ORCID: https://orcid.org/0000-0001-5249-3618)
- L. Kaufmann
- Albert Bothe
- Bahram Amiri
- Sophie Besser
- Daria Geilen
Institutions
- Kafrelsheikh University (EG)
- Thorlabs (Germany) (DE)
- Bayer (Switzerland) (CH)
- Jena University Hospital (DE)
- Bayer (Germany) (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.3389/fphar.2025.1528748
- Citations
- 13
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 10.48