Does viral circulation in slums have a global impact? The lesson learned from SARS-CoV-2 circulation in Complexo de favelas da Maré, Rio de Janeiro, Brazil
Because of growing inequalities, more than one-third of the worldwide population is expected to live in slums by 2050. Although slum dwellers are at increased risk of infectious diseases, this population may have been overlooked with respect to the sustainability of virus evolution. In this study, we aimed to analyze the genetic diversity and evolution of SARS-CoV-2 in the <i>Complexo de Favelas da Maré</i> slum, Rio de Janeiro, Brazil, and assess its impact on the global spread of the virus. We found that this slum harbored multiple strains of SARS-CoV-2, and its amplification and genetic diversity connected with the global circulation from 2020 to 2022. Thus, enhancing surveillance in slums could be important for future epidemic/pandemic preparedness by connecting virus genetic diversity in this region with its circulation at divergent locations.
Authors
- Thiago Moreno L. Souza (ORCID: https://orcid.org/0000-0003-2212-3899)
- Amanda De Araújo Batista Da Silva (ORCID: https://orcid.org/0000-0001-8256-2178)
- Rhaymá do Carmo Silva (ORCID: https://orcid.org/0000-0002-4388-6396)
- Aline de Paula Dias da Silva (ORCID: https://orcid.org/0009-0003-5022-0642)
- Monique Cristina dos Santos (ORCID: https://orcid.org/0009-0001-1700-4329)
- Patrı́cia T. Bozza (ORCID: https://orcid.org/0000-0001-8349-9529)
- Natalia Fintelman‐Rodrigues (ORCID: https://orcid.org/0000-0002-2332-8338)
- Marcelo Alves Ferreira (ORCID: https://orcid.org/0000-0003-4181-760X)
- Fernando A. Bozza (ORCID: https://orcid.org/0000-0003-4878-0256)
- Victor Corrêa Seixas
Institutions
- Universidade Federal Fluminense (BR)
- Pontifícia Universidade Católica do Rio de Janeiro (BR)
- D’Or Institute for Research and Education (BR)
- Instituto Evandro Chagas (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.3389/fmicb.2025.1483895
- Citations
- 1
- Primary Topic
- COVID-19 epidemiological studies
- Type
- article
- Field-Weighted Citation Impact
- 1.37
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro