An exploratory fetal MRI study examining the impact of 22q11.2 microdeletion syndrome on early brain growth
This exploratory study expands our existing knowledge on neurodevelopmental impairments in 22qDS to the fetal period by highlighting reduced white matter volumes compared to gestation and sex-matched control fetuses during this time-period. Our findings suggest that impaired white matter growth in fetuses with both 22qDS and CHD may not be fully explained by any underlying CHD.
Authors
- Reza Razavi (ORCID: https://orcid.org/0000-0003-1065-3008)
- Kuberan Pushparajah (ORCID: https://orcid.org/0000-0003-1541-1155)
- Alexandra F. Bonthrone (ORCID: https://orcid.org/0000-0001-5487-5564)
- Serena J. Counsell (ORCID: https://orcid.org/0000-0002-8033-5673)
- Johannes K. Steinweg (ORCID: https://orcid.org/0000-0002-3366-0932)
- Daniel Cromb (ORCID: https://orcid.org/0000-0002-9814-8841)
- Alena Uus (ORCID: https://orcid.org/0000-0001-5796-2145)
- Milou P.M. van Poppel (ORCID: https://orcid.org/0000-0002-1739-4726)
- David Lloyd (ORCID: https://orcid.org/0000-0003-1759-6106)
- Tom Finck (ORCID: https://orcid.org/0000-0002-9229-3183)
- Mary Rutherford (ORCID: https://orcid.org/0000-0003-3361-1337)
Institutions
- King's College London (GB)
- TUM Klinikum (DE)
Publication Details
- Journal
- Journal of Neurodevelopmental Disorders
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1186/s11689-025-09594-9
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- King's College London
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Centre For Medical Engineering, King’s College London