Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice
Taken together, our results suggested that sinensetin could alleviate HIRI injury through suppressing GRP78/CHOP-mediated ER stress, which may provide a novel therapeutic strategy for treating liver ischemia-reperfusion injury in clinical practice.
Authors
- Yanyan Jiang (ORCID: https://orcid.org/0000-0002-5268-9896)
- Hongbo Liu (ORCID: https://orcid.org/0000-0002-0733-8616)
- Yulin Peng (ORCID: https://orcid.org/0000-0001-6070-9917)
- Yihong Yang (ORCID: https://orcid.org/0000-0001-9138-7826)
- Guanghua Xiong (ORCID: https://orcid.org/0000-0002-1032-5218)
- Huangqi Shi
- Min Lu (ORCID: https://orcid.org/0000-0003-1345-1698)
- Jinghong Liu (ORCID: https://orcid.org/0009-0006-7215-7471)
- Yong Liu (ORCID: https://orcid.org/0009-0004-0062-3395)
Institutions
- Fuyang Normal University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.3389/fphar.2025.1519497
- Citations
- 4
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- National Natural Science Foundation of China
- Anhui Provincial Department of Education
- Fuyang Normal University