Unique gating strategy identifier based on the Prime Population System and Gödel Numbers

Gating is a fundamental and essential process in cytometry data analysis since it defines cell types of interest. Currently, there is no universally accepted method for representing and sharing gating strategies among software, publications, and repositories. I propose using the Prime Population system combined with a modified version of Gödel Numbers to identify any gating strategy uniquely. The Prime Population System is first used to identify gates on bivariate plots; successively, Gödel Numbers are used to set the sequence of the hierarchical gating strategy. The process results are unique identifiers for any existing and future gating strategy. The unique identifiers hold since according to the fundamental theorem of arithmetic, every natural number other than one either is a prime or is a product of prime numbers, and every nonprime number can be factored into a product of prime in only one way. This method represents a further step towards the arithmetization of cytometry metadata.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-02-12
DOI
https://doi.org/10.3389/fimmu.2025.1481412
Primary Topic
Cell Image Analysis Techniques
Type
article
Field-Weighted Citation Impact
0.00

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article

Unique gating strategy identifier based on the Prime Population System and Gödel Numbers

Antonio Cosma
Frontiers in Immunology
Cell Image Analysis Techniques
article

Unique gating strategy identifier based on the Prime Population System and Gödel Numbers

Antonio Cosma
article en

Abstract

Gating is a fundamental and essential process in cytometry data analysis since it defines cell types of interest. Currently, there is no universally accepted method for representing and sharing gating strategies among software, publications, and repositories. I propose using the Prime Population system combined with a modified version of Gödel Numbers to identify any gating strategy uniquely. The Prime Population System is first used to identify gates on bivariate plots; successively, Gödel Numbers are used to set the sequence of the hierarchical gating strategy. The process results are unique identifiers for any existing and future gating strategy. The unique identifiers hold since according to the fundamental theorem of arithmetic, every natural number other than one either is a prime or is a product of prime numbers, and every nonprime number can be factored into a product of prime in only one way. This method represents a further step towards the arithmetization of cytometry metadata.

Frontiers in ImmunologyVol. 16
Luxembourg Institute of Health (LU)
Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche
Openalex Percentile: Top 98%
Cell Image Analysis Techniques
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Unique gating strategy identifier based on the Prime Population System and Gödel Numbers — Antonio Cosma · Frontiers in Immunology (2025) | TGRS Research Map | TGRS