Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease
There is a bidirectional relationship between depression and ADL in patients with PD. Furthermore, we found that cognitive function mediates the relationship that exists between depression and ADL in patients with PD. Interventions aimed at enhancing cognitive function could potentially lessen the vicious cycle of depression and ADL in PD, thus improving patient quality of life (QOL).
Authors
- Hongmei Yu (ORCID: https://orcid.org/0000-0002-9852-2485)
- Meiqi Dong
- Durong Chen (ORCID: https://orcid.org/0000-0001-6990-2000)
- Yanqing Han (ORCID: https://orcid.org/0000-0002-9817-4337)
- Yue Xu (ORCID: https://orcid.org/0000-0002-8065-8253)
- Yun Zhang (ORCID: https://orcid.org/0000-0003-3578-6990)
Institutions
- Shanxi Medical University (CN)
- Shanxi Cardiovascular Hospital (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-02-12
- DOI
- https://doi.org/10.3389/fnagi.2025.1513373
- Citations
- 5
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.95
Funders
- National Natural Science Foundation of China