Quantification and correlation of amyloid-β plaque load, glial activation, GABAergic interneuron numbers, and cognitive decline in the young TgF344-AD rat model of Alzheimer’s disease
Pronounced neuropathological changes were found in the hippocampus and mPFC of young TgF344-AD rats, including the loss of hippocampal cholecystokinin-positive interneurons. Some of these neuropathological changes were negatively correlated with amyloid-β plaque load, but not with cognitive impairment.
Authors
- Anett Futácsi
- Gergely Szarka (ORCID: https://orcid.org/0000-0001-8121-2600)
- Ove Wiborg (ORCID: https://orcid.org/0000-0002-0555-2811)
- Boldizsár Czéh (ORCID: https://orcid.org/0000-0002-4926-5400)
- Béla Völgyi (ORCID: https://orcid.org/0000-0001-7481-390X)
- Kitti Rusznák
Institutions
- University of Pecs (HU)
- Aalborg University (DK)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-02-12
- DOI
- https://doi.org/10.3389/fnagi.2025.1542229
- Citations
- 3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49