Different lysine-to-methionine ratios in a low-protein diet affect the microbiome and metabolome, influencing the jejunal barrier function in Tibetan sheep
Collectively, our results suggest that the dietary Met/ Lys ratio could affect the jejunal SCFA concentration by modulating the microbial community and regulating metabolism, thereby contributing to jejunal barrier function. Our findings provide a theoretical basis for the application of Lys/Met diet supplementation in the nutritional management of Tibetan sheep, particularly when reducing the dietary crude protein (CP) level.
Authors
- Shengzhen Hou (ORCID: https://orcid.org/0000-0003-3842-5509)
- Fengshuo Zhang (ORCID: https://orcid.org/0009-0006-4281-9147)
- Linsheng Gui (ORCID: https://orcid.org/0000-0001-6392-3513)
- Yu Zhang (ORCID: https://orcid.org/0009-0005-1172-8923)
- Zhenling Wu (ORCID: https://orcid.org/0009-0007-7981-411X)
- Quyangangmao Su (ORCID: https://orcid.org/0009-0005-4476-1121)
- Xuan Chen (ORCID: https://orcid.org/0009-0002-7809-5911)
- Kaina Zhu (ORCID: https://orcid.org/0009-0006-2779-7824)
Institutions
- Qinghai University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.3389/fmicb.2025.1441143
- Citations
- 4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 3.22