Microbial dynamics of acute pancreatitis: integrating culture, sequencing, and bile impact on bacterial populations and gaseous metabolites
The abundant production of hydrogen may substantially impact enzymatic processes, inducing specific alterations in disulfide bonds and trypsin inactivation. Our investigation alludes to the conceivable active involvement of bile in effecting qualitative and quantitative modifications in the peripancreatic microbiota composition, establishing a correlation between released bile and bacterial generation of gaseous metabolites.
Authors
- Agata Pietrzyk
- Edyta Golińska (ORCID: https://orcid.org/0000-0001-8612-8897)
- Agnieszka Chmielarczyk (ORCID: https://orcid.org/0000-0002-0814-8638)
- Maria Kulecka (ORCID: https://orcid.org/0000-0002-9830-8892)
- Konrad Szaciłowski (ORCID: https://orcid.org/0000-0002-1596-9856)
- Magdalena Strus (ORCID: https://orcid.org/0000-0002-7437-5230)
- Natalia Żeber‐Lubecka (ORCID: https://orcid.org/0000-0003-4036-3191)
- Katarzyna Jedlińska (ORCID: https://orcid.org/0000-0002-8671-6266)
- Krzysztof Mech (ORCID: https://orcid.org/0000-0002-0119-8456)
- Agata Kuziak (ORCID: https://orcid.org/0000-0002-4491-6665)
- Antoni Szczepanik (ORCID: https://orcid.org/0000-0002-0244-7629)
- Anna Tomusiak-Plebanek (ORCID: https://orcid.org/0000-0003-4710-7983)
Institutions
- Jagiellonian University (PL)
- Postgraduate School of Molecular Medicine (PL)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- AGH University of Krakow (PL)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.3389/fmicb.2025.1544124
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00