Aortic intimal sarcoma with abdominal metastasis: case report and management approach

Aortic intimal sarcoma is a rare neoplasm with limited treatment options. MDM2 overexpression is commonly observed, but similar histological features can appear in other conditions, making diagnosis challenging. Imaging modalities, including MRI and PET-CT, are crucial for diagnosis and monitoring. Current treatment strategies are non-standardized, but small-molecule inhibitors targeting MDM2 show promise. This case highlights the potential effectiveness of combined surgical and chemotherapeutic approaches for managing abdominal metastasis of aortic intimal sarcoma and provides a foundation for future clinical trials.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-02-12
DOI
https://doi.org/10.3389/fonc.2025.1508691
Primary Topic
Cardiac tumors and thrombi
Type
article
Field-Weighted Citation Impact
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article

Aortic intimal sarcoma with abdominal metastasis: case report and management approach

Gehong Yao, Jianwei Xu
Frontiers in Oncology
Cardiac tumors and thrombi
article

Aortic intimal sarcoma with abdominal metastasis: case report and management approach

Gehong Yao, Jianwei Xu
article en

Abstract

Aortic intimal sarcoma is a rare neoplasm with limited treatment options. MDM2 overexpression is commonly observed, but similar histological features can appear in other conditions, making diagnosis challenging. Imaging modalities, including MRI and PET-CT, are crucial for diagnosis and monitoring. Current treatment strategies are non-standardized, but small-molecule inhibitors targeting MDM2 show promise. This case highlights the potential effectiveness of combined surgical and chemotherapeutic approaches for managing abdominal metastasis of aortic intimal sarcoma and provides a foundation for future clinical trials.

Frontiers in OncologyVol. 15
Zhejiang Chinese Medical University (CN), Huzhou Normal University (CN), Huzhou Central Hospital (CN)
Good health and well-being
Openalex Percentile: Top 95%
Cardiac tumors and thrombi
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Aortic intimal sarcoma with abdominal metastasis: case report and management approach — Gehong Yao, Jianwei Xu · Frontiers in Oncology (2025) | TGRS Research Map | TGRS