Treatment efficacy for infantile epileptic spasms syndrome in children with trisomy 21
In our cohort, epileptic spasms were the first presenting seizure type in all children with trisomy 21. Among first-line standard treatment options, ACTH may have superior efficacy for clinical and electrographic outcomes for IESS in children with trisomy 21.
Authors
- Rani K. Singh (ORCID: https://orcid.org/0000-0001-9343-6070)
- Henry Chen (ORCID: https://orcid.org/0000-0003-3455-0222)
- Renée A. Shellhaas (ORCID: https://orcid.org/0000-0002-3175-3908)
- Li‐Rong Shao (ORCID: https://orcid.org/0000-0002-0624-7122)
- John R. Mytinger (ORCID: https://orcid.org/0000-0001-7901-3960)
- Adam L. Numis
- Shaun A. Hussain (ORCID: https://orcid.org/0000-0001-6947-8852)
- Kelly G. Knupp (ORCID: https://orcid.org/0000-0002-1967-0827)
- Danielle Takacs
- Debopam Samanta (ORCID: https://orcid.org/0000-0002-5154-8717)
- Carl E. Stafstrom (ORCID: https://orcid.org/0000-0002-4432-2453)
Institutions
- Nationwide Children's Hospital (US)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- Washington University in St. Louis (US)
- Johns Hopkins Medicine (US)
- Levine Children's Hospital (US)
- UCSF Benioff Children's Hospital (US)
- Texas Children's Hospital (US)
- Wake Forest University (US)
- University of Colorado Anschutz Medical Campus (US)
- The Ohio State University (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-02-12
- DOI
- https://doi.org/10.3389/fped.2025.1498425
- Citations
- 2
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Pediatric Epilepsy Research Foundation
- Epilepsiatutkimussäätiö
- Epilepsy Society