High-throughput in vitro drug screening and in vivo studies identify fenretinide as a brain-penetrant DMG therapeutic
This comprehensive study has identified new DMG therapeutic vulnerabilities and highlights fenretinide as a brain-penetrant, anti-DMG agent.
Authors
- Maria Tsoli (ORCID: https://orcid.org/0000-0003-1155-0510)
- Han Shen (ORCID: https://orcid.org/0000-0003-2435-2150)
- Aaminah Khan (ORCID: https://orcid.org/0000-0002-4991-3308)
- Nicole Yeung (ORCID: https://orcid.org/0000-0002-9855-5789)
- Dannielle Upton (ORCID: https://orcid.org/0000-0002-4091-4208)
- David S. Ziegler (ORCID: https://orcid.org/0000-0001-7451-7916)
- Santosh Valvi (ORCID: https://orcid.org/0000-0002-9655-0001)
- Chelsea Mayoh (ORCID: https://orcid.org/0000-0002-6398-3046)
- Giovanna Farruggia (ORCID: https://orcid.org/0000-0003-3599-7034)
- C. Patrick Reynolds (ORCID: https://orcid.org/0000-0002-2827-8536)
- Benjamin S. Rayner (ORCID: https://orcid.org/0000-0002-3446-2241)
- Anjana Gopalakrishnan (ORCID: https://orcid.org/0009-0004-2146-0433)
- Isabella Orienti (ORCID: https://orcid.org/0000-0003-1972-2807)
- Pooja Venkat (ORCID: https://orcid.org/0000-0002-9171-7562)
- Anahid Ehteda (ORCID: https://orcid.org/0000-0002-4118-1499)
- Caitlin Ung (ORCID: https://orcid.org/0000-0001-9024-2772)
- Laura Franshaw
- Holly Holliday (ORCID: https://orcid.org/0000-0002-3022-0114)
- Jie Liu (ORCID: https://orcid.org/0000-0002-5608-6515)
- Sandra George
- Hieu Trung Nguyen
- Ruby Pandher
Institutions
- Texas Tech University (US)
- Cancer Institute of New South Wales (AU)
- UNSW Sydney (AU)
- Sydney Children's Hospital (AU)
- Texas Tech University Health Sciences Center (US)
- University of Bologna (IT)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1093/neuonc/noaf035
- Citations
- 1
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.81