RELATIONSHIP BETWEEN ALCOHOL -RELATED BRAIN DYSFUNCTION AND BRAIN PERFUSION SPECT

Abstract Background In Japan, the nationwide survey for assessing the prevalence of alcohol dependence syndrome per the ICD-10 criteria estimated that the number of individuals with alcohol dependence syndrome was 1.09 million. One notable finding is the steep increase in alcohol consumption among the elder person. Alcohol-related brain dysfunction has become a serious social problem in Japan. It is a form of dementia caused by long-term, excessive consumption of alcoholic beverages, resulting in neurological damage and impaired cognitive function. Certain individuals with alcohol-related brain dysfunction present with damage to the frontal lobes of their brain causing disinhibition, loss of planning and executive functions. In this time focus on the Alcoholics, we conducted a survey of alcohol-related cognitive dysfunction and related cerebral blood flow(CBF) by the RI scintigraphy. Method Subjects were 11 alcoholics and 34 healthy controls. To evaluate regional patterns of CBF, Z-score analysis was carried. To evaluate regional patterns of CBF alterations, two-sample t-test values were calculated on a pixel- by-pixel basis between Alcoholics and normal control. To evaluate their correlation between the CBF and Frontal Assessment Battery(FAB) was examined using Pearson's correlation coefficient. Results Compare with the normal control, we found that alcoholics have a significant reduction of the blood flow at the medial frontal lobe and we found a significant correlation between the FAB scale and the CBF decreasing (r=0.683, p<0.05) suggesting that frontal dysfunction and frontal blood flow are associated with each other. We will show the detail contents in this presentation.