Therapeutic Potential of Mesenchymal Stem Cells or their Secretome in Diabetic Mice with or without Preconditioning Treatment
In the present study, we concluded that UCMSC, CM, and UCMSC and CM preconditioned with synthetic and natural immunosuppressants and immunomodulators have the ability to regenerate damaged pancreatic beta cells and have an antidiabetic activity, along with an immunomodulating effect. This therapy is a promising choice for future research.
Authors
- Ramesh Bhonde
- Avinash Sanap (ORCID: https://orcid.org/0000-0003-2535-0958)
- Niyaz Ahmed (ORCID: https://orcid.org/0000-0001-6425-7583)
- Shivani Desai (ORCID: https://orcid.org/0000-0001-6069-7354)
- Snehal Satpute
- Surabhi Jarare
- Krushna Abhale
- Omkar Janjire
- Veeranjaneyulu Addepalli
- Anusaya Soundankar
Institutions
- Serum Institute of India (India) (IN)
- Dr. D. Y. Patil Medical College, Hospital and Research Centre (IN)
- Dr. D.Y. Patil Vidyapeeth, Pune (IN)
- Dr D Y Patil Dental College & Hospital (IN)
Publication Details
- Journal
- Recent Advances in Inflammation & Allergy Drug Discovery
- Published
- 2025-02-12
- DOI
- https://doi.org/10.2174/0127722708323777250121224618
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00