Transmission of Dolutegravir resistance in treatment-naive individuals with HIV-1: A cohort study
This study did not demonstrate transmitted DTG resistance among treatment-naive HIV-1-infected individuals. The findings suggest that DTG remains a safe and effective first-line ART option. However, close monitoring of viral load is recommended for all patients on DTG-containing ART regimens. Additionally, genotypic resistance testing should be performed on individuals who experience virological failure or a significant decline in CD4 + cell counts, with close attention to ART adherence.
Authors
- Fabiana Barbosa Assumpção de Souza (ORCID: https://orcid.org/0000-0001-8098-5417)
- Jorge Francisco da Cunha Pinto (ORCID: https://orcid.org/0000-0002-2974-2687)
- Natália Melo (ORCID: https://orcid.org/0000-0001-8815-0369)
- Amílcar Tanuri (ORCID: https://orcid.org/0000-0003-0570-750X)
- Cynthia Chester Cardoso (ORCID: https://orcid.org/0000-0003-0565-7047)
- Érica Ramos dos Santos Nascimento (ORCID: https://orcid.org/0000-0001-9236-9881)
- Lídia Theodoro Boullosa (ORCID: https://orcid.org/0000-0001-5428-4748)
- Laura Jane Gomes (ORCID: https://orcid.org/0000-0003-1526-7456)
- Débora Viana Freitas
- Sara Gonzalez Viega
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Hospital Universitário Gaffrée e Guinle (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- The Brazilian Journal of Infectious Diseases
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1016/j.bjid.2025.104513
- Citations
- 1
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.40