Transcriptome analysis of early‐ and late‐onset Alzheimer's disease in Korean cohorts
Analysis identified 18 and 88 dysregulated genes in early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD), respectively. Expression levels of SMOX and PLVAP were downregulated in LOAD. Expression levels of SMOX and PLVAP were associated with brain amyloid beta deposition. Pathways including mitophagy and 5' adenosine monophosphate-activated protein kinase signaling were enriched in a LOAD module. A LOAD module was highly preserved across two independent cohorts.
Authors
- SangYun Kim (ORCID: https://orcid.org/0000-0002-9101-5704)
- Joo‐Yeon Lee (ORCID: https://orcid.org/0000-0001-7879-5876)
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Sang‐Won Han (ORCID: https://orcid.org/0000-0002-8299-9481)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Tamina Park
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Joohon Sung (ORCID: https://orcid.org/0000-0001-9948-0160)
- Jung‐Min Pyun (ORCID: https://orcid.org/0000-0002-8391-5729)
- Jaeyeon Jeong (ORCID: https://orcid.org/0000-0002-2519-9429)
- Paula J. Bice (ORCID: https://orcid.org/0000-0001-5357-9966)
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Sunmin Yun
- Kwangsik Nho (ORCID: https://orcid.org/0000-0002-7624-3872)
- Shiwei Liu (ORCID: https://orcid.org/0000-0001-5526-6883)
- Dong Young Lee
- Young Ho Park (ORCID: https://orcid.org/0000-0002-2756-1786)
- Jeong Su Park (ORCID: https://orcid.org/0000-0001-5149-1362)
- Jiyun Hwang
Institutions
- Seoul National University (KR)
- Hallym University (KR)
- Soonchunhyang University Hospital Seoul (KR)
- Seoul National University Bundang Hospital (KR)
- Hallym University Chuncheon Sacred Heart Hospital (KR)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14563
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Seoul National University Bundang Hospital
- National Research Foundation
- Seoul National University
- Hallym University
- National Research Foundation of Korea
- Hallym University Medical Center
- Ministry of Science and ICT, South Korea
- National Institute on Aging
- National Institute of General Medical Sciences
- U.S. National Library of Medicine
- National Center for Advancing Translational Sciences