Predicting survival rate by plasma biomarkers and clinical variables in syndromes associated with frontotemporal lobar degeneration
Plasma neurofilament light chain and clinical variables can predict survival in frontotemporal lobar degeneration (FTLD)-associated syndromes. FTLD Survival Score (FTLD-SS), computed with survival predictors, may serve as a simple tool for patient stratification. FTLD-SS is associated with greater atrophy in frontal and putamen areas.
Authors
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Hanna Huber (ORCID: https://orcid.org/0009-0004-3080-6870)
- Enrico Premi (ORCID: https://orcid.org/0000-0002-4342-6963)
- Roberto Gasparotti (ORCID: https://orcid.org/0000-0002-2591-2415)
- Giancarlo Logroscino (ORCID: https://orcid.org/0000-0003-0423-3242)
- Mario Grassi (ORCID: https://orcid.org/0000-0001-6612-8566)
- Barbara Tarantino (ORCID: https://orcid.org/0000-0001-6384-2561)
- Valentina Cantoni (ORCID: https://orcid.org/0000-0002-9933-5649)
- Kaj Blennow
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Barbara Borroni (ORCID: https://orcid.org/0000-0001-9340-9814)
- Valeria Bracca
- Maria Sofia Cotelli (ORCID: https://orcid.org/0000-0002-7010-2809)
- Andréa L. Benedet
- Kübra Tan (ORCID: https://orcid.org/0000-0002-9092-2118)
Institutions
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- University of Arizona (US)
- University of Pavia (IT)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Banner Sun Health Research Institute (US)
- Institut du Cerveau (FR)
- University College London (GB)
- University of Bari Aldo Moro (IT)
- University of Brescia (IT)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14558
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- University College London
- European Commission
- Vetenskapsrådet
- UK Dementia Research Institute