Identifying Daytime Hypercapnia Using Transcutaneous Carbon Dioxide Monitoring in Patients With Amyotrophic Lateral Sclerosis
TcCO<sub>2</sub> monitoring identified strengths and weaknesses of PFTs in identifying hypercapnia in ALS. We found high sensitivity of |MIP| < 60 cmH<sub>2</sub>O and FVC < 80% predicted and high specificity of FVC < 50% predicted. Prospective studies should investigate the optimal clinical role for tcCO<sub>2</sub>.
Authors
- Jesse Y. Hsu (ORCID: https://orcid.org/0000-0002-1522-6534)
- Philip J. Choi (ORCID: https://orcid.org/0000-0003-3609-5999)
- Jason Ackrivo (ORCID: https://orcid.org/0000-0003-4379-1255)
- José Víctor Jiménez (ORCID: https://orcid.org/0000-0002-9209-0327)
- Lauren Elman (ORCID: https://orcid.org/0000-0003-4706-950X)
- Alexander H. Morrison (ORCID: https://orcid.org/0000-0002-6141-5352)
Institutions
- Yale New Haven Hospital (US)
- The Ohio State University Wexner Medical Center (US)
- New York University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1002/mus.28366
- Citations
- 2
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Muscular Dystrophy Association
- National Institutes of Health