Biodegradable Electrospun PLGA Nanofibers-Encapsulated Trichinella Spiralis Antigens Protect from Relapsing Experimental Autoimmune Encephalomyelitis and Related Gut Microbiota Dysbiosis
The delivery of <i>T. spiralis</i> ESL1 antigens via biodegradable electrospun PLGA nanofiber implants efficiently protected the animals from developing EAE by inducing a beneficial immune response in the spleen, gut, and CNS. This platform provides excellent grounds for further development of novel MS therapies.
Authors
- Ljiljana Sofronić‐Milosavljević (ORCID: https://orcid.org/0000-0002-2721-125X)
- Saša Vasilev (ORCID: https://orcid.org/0000-0001-7870-2713)
- Nataša Golić (ORCID: https://orcid.org/0000-0001-7419-9743)
- Dušan Radojević (ORCID: https://orcid.org/0000-0002-6287-6310)
- Petar S. Uskoković (ORCID: https://orcid.org/0000-0001-9543-1732)
- Jelena Đokić (ORCID: https://orcid.org/0000-0002-5669-8175)
- Dušica Stojanović (ORCID: https://orcid.org/0000-0001-6308-7586)
- Alisa Gruden‐Movsesijan (ORCID: https://orcid.org/0000-0002-3061-5474)
- Miroslav Dinić (ORCID: https://orcid.org/0000-0001-5275-4531)
- Sergej Tomić (ORCID: https://orcid.org/0000-0003-2570-1295)
- Ljiljana Sabljić (ORCID: https://orcid.org/0000-0001-6027-591X)
- Sofija Glamočlija (ORCID: https://orcid.org/0000-0003-0497-5852)
- Nataša Radulović
Institutions
- University of Belgrade (RS)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/ijn.s499161
- Citations
- 2
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 4.01