A brain DNA co‐methylation network analysis of psychosis in Alzheimer's disease
DNA methylation was assessed in the prefrontal cortex in subjects with AD+P and AD-P. WGCNA identified six modules of co-methylated loci associated with AD+P in a discovery cohort. One of the modules was replicated in an independent cohort. This module was enriched for synaptic genes and in excitatory and inhibitory neurons. mQTLs mapping to genes in the module co-localized with GWAS loci for schizophrenia and educational attainment.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Ali Torkamani (ORCID: https://orcid.org/0000-0003-0232-8053)
- Geir Selbæk (ORCID: https://orcid.org/0000-0001-6511-8219)
- Jennifer Imm (ORCID: https://orcid.org/0000-0002-8827-8669)
- Ehsan Pishva (ORCID: https://orcid.org/0000-0002-8964-0682)
- Clive Ballard (ORCID: https://orcid.org/0000-0003-0022-5632)
- Jonathan S. Mill (ORCID: https://orcid.org/0000-0003-1115-3224)
- Morteza Kouhsar (ORCID: https://orcid.org/0000-0001-6092-3016)
- Luke Weymouth (ORCID: https://orcid.org/0000-0002-1168-6015)
- Sverre Bergh (ORCID: https://orcid.org/0000-0001-9593-2967)
- Katie Lunnon (ORCID: https://orcid.org/0000-0001-7570-6065)
- Adam R. Smith (ORCID: https://orcid.org/0000-0001-6495-2711)
- Robert A. Sweet (ORCID: https://orcid.org/0000-0001-9154-9709)
- Yehani Wedatilake (ORCID: https://orcid.org/0000-0002-9268-7385)
- Byron Creese (ORCID: https://orcid.org/0000-0001-6490-6037)
- Claudia Bredemeyer
Institutions
- Scripps Research Institute (US)
- Oslo University Hospital (NO)
- University of Pittsburgh (US)
- Innlandet Hospital Trust (NO)
- University of Exeter (GB)
- Sykehuset i Vestfold (NO)
- Maastricht University (NL)
- Brunel University of London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14501
- Citations
- 6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- University of Pittsburgh
- National Institute for Health and Care Research
- Department of Health and Social Care
- ZonMw
- Alzheimer Nederland
- National Institutes of Health
- Helse Sør-Øst RHF
- National Institute on Aging
- National Institute of Mental Health
- National Center for Advancing Translational Sciences