Tracer kinetic model detecting heterogeneous blood–brain barrier permeability to water and contrast agent in Alzheimer's disease and dementia with Lewy bodies
We measured blood-brain barrier (BBB) permeability to water and contrast agent based on dynamic contrast-enhanced magnetic resonance imaging. Alzheimer's disease (AD) is characterized by lower water exchange rates across the BBB. Dementia with Lewy bodies exhibits higher BBB permeability to contrast agent. BBB permeability is related to cognitive impairment and disease burden. BBB permeability to water was negatively associated with that to contrast agent.
Authors
- Ziming Xu
- Jiaqi Dou (ORCID: https://orcid.org/0009-0001-6842-9378)
- Yong Ji (ORCID: https://orcid.org/0000-0003-0745-1528)
- Jinghuan Gan (ORCID: https://orcid.org/0000-0002-8840-2834)
- Hao Lu (ORCID: https://orcid.org/0000-0002-0322-4400)
- Xiaoqi Lin (ORCID: https://orcid.org/0000-0002-0760-3950)
- Hao Wu (ORCID: https://orcid.org/0000-0001-7096-2027)
- Rui Li (ORCID: https://orcid.org/0000-0002-1973-742X)
- Yajie Wang (ORCID: https://orcid.org/0000-0001-7259-3886)
- Zhichao Chen (ORCID: https://orcid.org/0000-0002-9884-0002)
- Wen Chen (ORCID: https://orcid.org/0000-0002-6996-8058)
- Huijun Chen (ORCID: https://orcid.org/0000-0003-1158-5510)
- Zhihong Shi (ORCID: https://orcid.org/0000-0002-7665-6685)
- Shuai Liu (ORCID: https://orcid.org/0000-0002-8775-3245)
Institutions
- Capital Medical University (CN)
- Beijing Tian Tan Hospital (CN)
- Tianjin Huanhu Hospital (CN)
- Beijing Friendship Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14529
- Citations
- 10
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 14.31
Funders
- National Natural Science Foundation of China
- Tsinghua University
- Beijing Municipal Science and Technology Commission
- Tianjin Municipal Education Commission
- National Key Clinical Specialty Discipline Construction Program of China
- Tianjin Science and Technology Program
- Tianjin Municipal Transportation Commission Science and Technology Development Plan Project