Alzheimer's disease patients have smaller venous drainage system compared to cognitively healthy controls
The non-jugular venous system, including the vertebral plexus and pterygopalatine plexus, plays an important role in cerebral drainage. The total venous CSA is significantly smaller in cognitively impaired patients compared to healthy controls. Reduced venous drainage may contribute to the accumulation of Aβ and other waste products and potentially plays a role in AD pathology.
Authors
- Eitan Auriel (ORCID: https://orcid.org/0000-0001-6712-5156)
- Keshet Pardo (ORCID: https://orcid.org/0000-0001-5056-2368)
- Felix Benninger (ORCID: https://orcid.org/0000-0003-3097-4693)
- Ilan Shelef (ORCID: https://orcid.org/0000-0002-8398-6455)
- Vadim Khasminsky
- Ilan Goldberg (ORCID: https://orcid.org/0000-0001-7420-4055)
- Ophir Keret (ORCID: https://orcid.org/0000-0002-9964-7888)
- Amir Glik (ORCID: https://orcid.org/0000-0002-1642-3994)
Institutions
- Tel Aviv University (IL)
- Rabin Medical Center (IL)
- Soroka Medical Center (IL)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14551
- Citations
- 4
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 3.64
Funders
- Alzheimer's Association
- Global Brain Health Institute
- European Commission