Modulation of Calcium Signaling on Demand to Decipher the Molecular Mechanisms of Primary Aldosteronism
H295R-S2 α7-5HT3-R cells are a new model reproducing the major features of cells harboring <i>KCNJ5</i> mutations. Increased expression of <i>CYP11B2</i> and stimulation of the mineralocorticoid biosynthesis pathway are associated with a decrease of cell proliferation and an increase of apoptosis, indicating that additional events may be required for the development of aldosterone-producing adenomas.
Authors
- Simon Travers (ORCID: https://orcid.org/0000-0003-0104-8260)
- Sheerazed Boulkroun (ORCID: https://orcid.org/0000-0002-8796-7534)
- Maria‐Christina Zennaro (ORCID: https://orcid.org/0000-0001-5449-9191)
- Scott M. Sternson (ORCID: https://orcid.org/0000-0002-0835-444X)
- May Fayad (ORCID: https://orcid.org/0009-0007-1665-7698)
- Christopher Magnus (ORCID: https://orcid.org/0000-0001-5640-0116)
- Nicolò Faedda (ORCID: https://orcid.org/0009-0005-5902-9769)
- Teresa Cosentino
- Stéphanie Baron (ORCID: https://orcid.org/0000-0002-0375-6968)
- Isabelle Giscos-Douriez
- Zeina R. Al Sayed (ORCID: https://orcid.org/0000-0002-0661-2003)
- David Pentón (ORCID: https://orcid.org/0000-0002-6425-3766)
- Bakhta Fedlaoui
- Jean‐Sébastien Hulot (ORCID: https://orcid.org/0000-0001-5463-6117)
- Fabio Luiz Fernandes-Rosa (ORCID: https://orcid.org/0000-0002-0162-0792)
- Rita Alexandre Coelho
Institutions
- Howard Hughes Medical Institute (US)
- Inserm (FR)
- University of Zurich (CH)
- Université Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- Paris Cardiovascular Research Center (FR)
- Fiat Chrysler Automobiles (France) (FR)
Publication Details
- Journal
- Hypertension
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1161/hypertensionaha.124.23295
- Citations
- 3
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 3.88