The Dementia SomaSignal Test (dSST): A plasma proteomic predictor of 20‐year dementia risk
The Dementia SomaSignal Test (dSST) predicts 20-year dementia risk across two independent cohorts. dSST outperforms existing plasma biomarkers in predicting multi-decade dementia risk. dSST predicts cognitive decline and accelerated brain atrophy in a third cohort. dSST is a prognostic aid that can predict dementia risk over two decades.
Authors
- Shintaro Kato (ORCID: https://orcid.org/0000-0001-6240-1326)
- Iwao Waga
- Keita Hiraga (ORCID: https://orcid.org/0000-0002-0134-2956)
- Melissa Simpson (ORCID: https://orcid.org/0000-0002-9411-8039)
- Kelsey M. Loupy (ORCID: https://orcid.org/0000-0002-7338-9104)
- Clare Paterson (ORCID: https://orcid.org/0000-0001-7454-560X)
- Güray Erus (ORCID: https://orcid.org/0000-0001-6633-4861)
- Yifei Lü (ORCID: https://orcid.org/0000-0001-8907-4898)
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Heather E. Dark (ORCID: https://orcid.org/0000-0001-7194-3637)
- Makio Furuichi
- Rebecca F. Gottesman (ORCID: https://orcid.org/0000-0002-9504-1256)
- Masaki Shibayama
- Josef Coresh (ORCID: https://orcid.org/0000-0002-4598-0669)
- Michael R. Duggan (ORCID: https://orcid.org/0000-0002-1029-4423)
- Hannah Biegel
- Priya Palta
- Rei Otsuka (ORCID: https://orcid.org/0000-0001-6184-570X)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Alexandria Lewis (ORCID: https://orcid.org/0000-0002-3812-8080)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Stephen A. Williams (ORCID: https://orcid.org/0000-0002-8661-4315)
- Yukiko Nishita (ORCID: https://orcid.org/0000-0002-2551-9605)
- Jenifer Cordon
- Murat Bilgel (ORCID: https://orcid.org/0000-0001-5042-7422)
- Naoto Kaneko
- Susan M. Resnick
- Masahisa Katsuno
Institutions
- University of North Carolina at Chapel Hill (US)
- National Institutes of Health (US)
- Intel (United States) (US)
- Johns Hopkins University (US)
- Tohoku University (JP)
- Johns Hopkins Medicine (US)
- National Institute of Neurological Disorders and Stroke (US)
- National Institute on Aging (US)
- National Center for Geriatrics and Gerontology (JP)
- New York University (US)
- Nagoya University (JP)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14549
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Nagoya University
- National Center for Geriatrics and Gerontology
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute on Deafness and Other Communication Disorders
- National Institute of Neurological Disorders and Stroke