Copper-Catalyzed Synthesis of Substituted 2-Amino (or 2-Alkoxy) Benzimidazoles from Amine (or Alcohol)-Trichloroacetonitrile Adduct and 2-Iodoaniline with Ultrasound Assistance

Using ultrasound, the synthesis of substituted 2-amino (or 2-alkoxy) benzimidazoles through a multi-component, one-pot reaction of 2-iodoaniline and amine (or alcohol)- trichloroacetonitrile (CCl<sub>3</sub>CN) adduct with the help of a catalytic amount of copper(I) iodide in dimethylformamide at room temperature has been presented. Using basic materials, simple and available reagents, gentle copper-catalyzed reaction conditions, easy purification with the help of solvent, decent efficiency, applying a simple and efficient sonochemical method, reacting in the shortest time, and finally, the synthesis of 18 new heterocycle compounds are appreciable features of this protocol.