Sweroside Modulates Oxidative Stress and Neuroplasticity-Related Gene Expression in Scopolamine-Treated Zebrafish
Overall, our findings suggested that Swe has a positive role in the cholinergic system activity and brain antioxidant status and showed for the first time that it can restore the downregulated expression of <i>bdnf, npy, egr1, nfr2a</i>, and <i>creb1</i> genes in the brain of the Sco-induced zebrafish model.
Authors
- Lucian Hriţcu (ORCID: https://orcid.org/0000-0001-6981-4174)
- Lucian Gorgan (ORCID: https://orcid.org/0000-0001-6454-9092)
- Omayma A. Eldahshan (ORCID: https://orcid.org/0000-0002-0972-0560)
- Walaa A. El‐Kashak (ORCID: https://orcid.org/0000-0002-4048-3700)
- Mohamed A. El Raey (ORCID: https://orcid.org/0000-0002-5960-3012)
- Ion Brinza (ORCID: https://orcid.org/0000-0003-3103-9728)
- Bogdan Alexandru Stache
- Marius Mihăşan (ORCID: https://orcid.org/0000-0003-4439-4251)
Institutions
- Ain Shams University (EG)
- Alexandru Ioan Cuza University (RO)
- Institutul Regional de Oncologie (RO)
- National Research Centre (EG)
Publication Details
- Journal
- CNS & Neurological Disorders - Drug Targets
- Published
- 2025-02-12
- DOI
- https://doi.org/10.2174/0118715273345712250119200430
- Citations
- 3
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 2.42