Polygonati Rhizoma Alleviates Vascular Dementia through Regulating Microglial Polarization Transitions Mediated by NF-κB/NLRP3 Pathway

PR could hamper inflammation and microglial polarization in 2VO-induced VaD and LPS-induced BV2 cells. Our results showed that PR was a promising Chinese herb to alleviate VaD, and the potential mechanism might be related to NF-κB/NLRP3 signaling pathway.

Authors

Yin Yuan (ORCID: https://orcid.org/0009-0000-9617-8417)
Tian Zhou (ORCID: https://orcid.org/0000-0002-7871-8798)
Xi Chen (ORCID: https://orcid.org/0000-0002-3160-614X)
Meng Li (ORCID: https://orcid.org/0000-0002-4040-7759)
Yihang Li (ORCID: https://orcid.org/0000-0001-5677-0440)

Institutions

Yunnan University (CN)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Xishuangbanna Tropical Botanical Garden (CN)

Publication Details

Journal: Current Pharmaceutical Biotechnology
Published: 2025-02-06
DOI: https://doi.org/10.2174/0113892010336948241209172018
Citations: 1
Primary Topic: Neurological Disease Mechanisms and Treatments
Type: article
Field-Weighted Citation Impact: 0.84

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article

Polygonati Rhizoma Alleviates Vascular Dementia through Regulating Microglial Polarization Transitions Mediated by NF-κB/NLRP3 Pathway

Yin Yuan, Tian Zhou, Xi Chen, Meng Li et al.

Feb 6, 2025

1 citations

Current Pharmaceutical Biotechnology

Neurological Disease Mechanisms and Treatments

0.84

article

Polygonati Rhizoma Alleviates Vascular Dementia through Regulating Microglial Polarization Transitions Mediated by NF-κB/NLRP3 Pathway

Yin Yuan, Tian Zhou, Xi Chen, Meng Li, Yihang Li

February 6, 2025article en

1 citations

Abstract

PR could hamper inflammation and microglial polarization in 2VO-induced VaD and LPS-induced BV2 cells. Our results showed that PR was a promising Chinese herb to alleviate VaD, and the potential mechanism might be related to NF-κB/NLRP3 signaling pathway.

Current Pharmaceutical BiotechnologyVol. 26

Yunnan University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Xishuangbanna Tropical Botanical Garden (CN)

Good health and well-being

Openalex Percentile: Top 30%

Neurological Disease Mechanisms and Treatments

0.84

DOI Source OpenAlex

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Polygonati Rhizoma Alleviates Vascular Dementia through Regulating Microglial Polarization Transitions Mediated by NF-κB/NLRP3 Pathway — Yin Yuan, Tian Zhou, et al. · Current Pharmaceutical Biotechnology (2025) | TGRS Research Map | TGRS