Integrative Multi-omics Analysis and Mendelian Randomization Reveal Potential Therapeutic Targets and their Stratification in Lung Squamous Cell Carcinoma
In this study, we identified 3 tier-one genes (MCM6, C4B, CTC-463A16.1), 7 tier-two genes (C4A, HLA-DRB9, LIMS2, LINC00654, MYO7B, SIGLEC5, TIE1), and 13 tier-three genes (AC007743.1, AC147651.4, ALDH2, BTN3A2, BTNL9, CCR1, GIPC3, HLA-DQB1, ICAM5, LIMD1, PM20D1, RP11-302L19.3, RP11-768F21.1).
Authors
- Xiaoyi Chen (ORCID: https://orcid.org/0000-0002-4428-4418)
- You‐Peng Chen (ORCID: https://orcid.org/0000-0002-7332-7464)
- Zhenglin Chang (ORCID: https://orcid.org/0000-0002-7083-6220)
- Yifei Xie (ORCID: https://orcid.org/0000-0002-8045-0698)
- Junquan Sun
- Xuntao Lai (ORCID: https://orcid.org/0009-0003-8985-0174)
- Enzhong Li
- Baoqing Sun
- Zhangkai J. Cheng
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Kingmed Diagnostics (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-02-12
- DOI
- https://doi.org/10.2174/0109298673334210241228062116
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00