Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgenic mice

Our findings demonstrate that the downregulation of SIRT1 expression exacerbates cognitive dysfunction by activating FOXO1 acetylation and promoting ERS-mediated apoptosis.

Authors

Institutions

Publication Details

Journal
Neuroprotection/Neuroprotection (Chichester, England. Print)
Published
2025-02-12
DOI
https://doi.org/10.1002/nep3.66
Citations
2
Primary Topic
FOXO transcription factor regulation
Type
article
Field-Weighted Citation Impact
1.61

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgenic mice

Chenfei Zheng, Yangping Shentu, Hanbing Yao, Xiaofang Fan et al.
2 citations
Neuroprotection/Neuroprotection (Chichester, England. Print)
FOXO transcription factor regulation
1.61
article

Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgenic mice

Chenfei Zheng, Yangping Shentu, Hanbing Yao, Xiaofang Fan, Shuqing Ma, Junming Fan, Zongyuan Zhao, K. Wang, Xianghong Yin, Nan Zhang, Jianmin Li, Hui Wang, Ying Zhou, Xiaoxiao Chen, Jing Zeng, Rong Liu, Bin Yang, Yunting Wang, Yongsheng Gong, Jingye Pan, Min Zhu
article en
2 citations

Abstract

Our findings demonstrate that the downregulation of SIRT1 expression exacerbates cognitive dysfunction by activating FOXO1 acetylation and promoting ERS-mediated apoptosis.

Neuroprotection/Neuroprotection (Chichester, England. Print)Vol. 3(2)
Wenzhou University (CN), Sichuan University (CN), Wenzhou Medical University (CN), First Affiliated Hospital of Wenzhou Medical University (CN), West China Hospital of Sichuan University (CN), University of Houston (US), Huazhong University of Science and Technology (CN)
Wenzhou Medical University, National Natural Science Foundation of China, Wenzhou Municipal Science and Technology Bureau
Openalex Percentile: Top 19%
FOXO transcription factor regulation
1.61
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.