Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgenic mice
Our findings demonstrate that the downregulation of SIRT1 expression exacerbates cognitive dysfunction by activating FOXO1 acetylation and promoting ERS-mediated apoptosis.
Authors
- Chenfei Zheng
- Yangping Shentu (ORCID: https://orcid.org/0009-0001-6171-0490)
- Hanbing Yao
- Xiaofang Fan (ORCID: https://orcid.org/0000-0002-7234-0093)
- Shuqing Ma (ORCID: https://orcid.org/0009-0000-9581-8216)
- Junming Fan (ORCID: https://orcid.org/0000-0003-1425-6712)
- Zongyuan Zhao
- K. Wang
- Xianghong Yin
- Nan Zhang (ORCID: https://orcid.org/0000-0002-6744-2810)
- Jianmin Li (ORCID: https://orcid.org/0000-0002-1162-9301)
- Hui Wang (ORCID: https://orcid.org/0000-0002-5132-0077)
- Ying Zhou (ORCID: https://orcid.org/0000-0002-3336-5757)
- Xiaoxiao Chen (ORCID: https://orcid.org/0000-0001-5497-8600)
- Jing Zeng (ORCID: https://orcid.org/0000-0002-4886-5682)
- Rong Liu (ORCID: https://orcid.org/0000-0001-7477-6520)
- Bin Yang (ORCID: https://orcid.org/0000-0002-6284-5573)
- Yunting Wang (ORCID: https://orcid.org/0000-0002-1616-2763)
- Yongsheng Gong (ORCID: https://orcid.org/0000-0001-8383-2934)
- Jingye Pan (ORCID: https://orcid.org/0000-0002-7745-9288)
- Min Zhu (ORCID: https://orcid.org/0000-0002-8417-9698)
Institutions
- Wenzhou University (CN)
- Sichuan University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- West China Hospital of Sichuan University (CN)
- University of Houston (US)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Neuroprotection/Neuroprotection (Chichester, England. Print)
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1002/nep3.66
- Citations
- 2
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- Wenzhou Municipal Science and Technology Bureau