Age- and Genotype-Dependent Effects of Chronic Nicotine on Presenilin1/2 Double Knockout Mice: From Behavior to Molecular Pathways
These findings demonstrate that nicotine's effects on cognition and molecular pathways are both age- and genotype-dependent, suggesting its therapeutic potential may be limited to specific stages of neurodegeneration while potentially having adverse effects in healthy aging brains.
Authors
- Youwen Si (ORCID: https://orcid.org/0000-0003-3093-6355)
- Fei-Yan Qi
- Bo Meng (ORCID: https://orcid.org/0000-0003-0433-5038)
Institutions
- Tobacco Research Institute (CN)
- Yunnan Academy of Agricultural Sciences (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Current Alzheimer Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2174/0115672050363992250127072919
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00