Inhibition of <scp>SARM1</scp> Reduces Neuropathic Pain in a Spared Nerve Injury Rodent Model
This study demonstrates that SARM1 KO rats are less sensitive to mechanical and cold nociception than WT rats in an SNI model with decreased inflammatory response. Given these results, inhibition of SARM1 should be further investigated in the treatment of neuropathic pain.
Authors
- Ronald S. Perez
- Christopher J. Dy (ORCID: https://orcid.org/0000-0003-1422-2483)
- Christopher G. Herbosa (ORCID: https://orcid.org/0000-0003-0314-3341)
- Alexandra Jaeger (ORCID: https://orcid.org/0009-0007-9843-5123)
- David M. Brogan (ORCID: https://orcid.org/0000-0001-6259-4885)
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1002/mus.28367
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases