Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy response
This study highlights the utility of isPLA in detecting distinct tumour-immune interactions within the TME, offering new cellular interaction metrics for stratifying and optimising immunotherapy strategies.
Authors
- Caroline Cooper (ORCID: https://orcid.org/0000-0002-3630-0019)
- Habib Sadeghirad (ORCID: https://orcid.org/0000-0002-1919-5958)
- Vahid Yaghoubi Naei (ORCID: https://orcid.org/0000-0003-3429-2614)
- Tony Blick
- Rahul Ladwa
- Arutha Kulasinghe (ORCID: https://orcid.org/0000-0003-3224-7350)
- Kenneth J. O’Byrne (ORCID: https://orcid.org/0000-0002-6754-5633)
- Majid Ebrahimi Warkiani (ORCID: https://orcid.org/0000-0002-4184-1944)
- James Monkman (ORCID: https://orcid.org/0000-0002-7219-8402)
- Brett Hughes (ORCID: https://orcid.org/0000-0002-1811-0537)
- Agata Zieba Wicher
- Sara Bodbin (ORCID: https://orcid.org/0000-0001-6054-7014)
- Meg L. Donovan (ORCID: https://orcid.org/0000-0002-9875-8914)
- Catherine Barnett (ORCID: https://orcid.org/0009-0009-5051-1750)
- Subham Basu
- Robert Stad
- Rafael Tubelleza
- Amelie Viratham
Institutions
- University of Technology Sydney (AU)
- The University of Queensland (AU)
- Royal Brisbane and Women's Hospital (AU)
- Wesley Hospital (AU)
- Princess Alexandra Hospital (AU)
- 1928 Diagnostics (Sweden) (SE)
- Akoya Biosciences (United States) (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1186/s12967-025-06186-y
- Citations
- 8
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 8.36
Funders
- PA Research Foundation
- Garnett Passe and Rodney Williams Memorial Foundation