Construction of tetravalent bispecific Tandab (CD3/BCMA)-secreting human umbilical cord mesenchymal stem cells and its efficiency in the treatment of multiple myeloma
These results suggest that UCMSCs releasing Tandab (CD3/BCMA) are a promising new tool for the treatment of MM, opening a new avenue for the development of cell-based therapy.
Authors
- Chaoyu Li
- Bo Ke (ORCID: https://orcid.org/0000-0002-7288-4971)
- Chunfang Kong (ORCID: https://orcid.org/0000-0003-1703-324X)
- Caishui Wan
- Liting Ding
- Wei Zuo (ORCID: https://orcid.org/0000-0002-4460-0337)
- Weirong Ding
- Mengshang Xiong
- Tingting Zhang (ORCID: https://orcid.org/0000-0001-9141-2593)
- Anna Li (ORCID: https://orcid.org/0000-0002-4702-7783)
- Yang Lü (ORCID: https://orcid.org/0000-0003-1845-7618)
- Qing-Dong Lu (ORCID: https://orcid.org/0000-0002-0582-2383)
- Lixia Cao
- Yutao Yan
- Junzhang Liu (ORCID: https://orcid.org/0009-0005-9684-0518)
Institutions
- Nanchang University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
- Education Department of Jiangxi Province (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1186/s13287-025-04212-w
- Citations
- 2
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province