Bi-Layer Tablets for Controlled Release Drug Delivery

Bilayer tablets has the potential for successful combination therapy as novel drug delivery system. Bilayer tablets are modified release system in which one layer serves as loading dose and the other layer serves as maintenance dose to enhance the bioavailability or to avoid the interaction between the incompatible substances by separating them physically. Several The development of bi-layer tablets for a variety of reasons like patent extension, therapeutic, and marketing purposes. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. The goal of this review article is to discuss different approaches, criteria for immediate and sustained release dosage form, manufacturing techniques of bilayer tablet technology. KEYWORDS: LOADING DOSE, INCOMPATIBLE, BILAYER TABLETS,THERAPEUTIC