Pericyte-derived extracellular vesicles improve vascular barrier function in sepsis via the Angpt1/PI3K/AKT pathway and pericyte recruitment: an in vivo and in vitro study
PCEVs protect against sepsis by regulating the vascular endothelial barrier, promoting PC recruitment, protecting intestinal function, and restoring properties via activation of the Angpt1/PI3K/AKT pathway.
Authors
- Xi Luo (ORCID: https://orcid.org/0000-0002-1742-2424)
- Heping Zhou (ORCID: https://orcid.org/0000-0002-7302-6821)
- Liangming Liu (ORCID: https://orcid.org/0000-0001-6001-8729)
- Zisen Zhang (ORCID: https://orcid.org/0000-0003-0098-2668)
- Yi-Yan Liu (ORCID: https://orcid.org/0000-0003-2234-3357)
- Daiqin Bao
- Tao Li (ORCID: https://orcid.org/0000-0002-8371-7060)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-2734-0115)
- Qinghui Li (ORCID: https://orcid.org/0000-0002-3847-3028)
- Ao Yang
- Jiatao Zang
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1186/s13287-025-04201-z
- Citations
- 8
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- National Natural Science Foundation of China
- Army Medical University
- Young Scientists Fund