Pre-vaccination immune markers predict response to BNT162b2 mRNA vaccine in vulnerable groups – The CONVERS project, report from a pediatric tertiary hospital
Pre-vaccination B and T-cell characteristics at both phenotypic and gene- expression level correlate with short- and long- term memory maintenance in VPs with lower immunogenicity upon BNT162b2 vaccine. Such signatures need to be validated in larger cohorts and may provide a predictive score to inform personalized and more effective vaccine interventions.
Authors
- Arianna Rotili (ORCID: https://orcid.org/0009-0003-2272-5184)
- Francesca Rocchi (ORCID: https://orcid.org/0000-0002-4255-0823)
- Veronica Santilli (ORCID: https://orcid.org/0000-0003-1329-6827)
- Emma Concetta Manno (ORCID: https://orcid.org/0009-0009-0095-8167)
- Alessia Neri (ORCID: https://orcid.org/0000-0002-6441-2800)
- Paola Zangari
- Chiara Rossetti (ORCID: https://orcid.org/0000-0001-8200-8724)
- G. Olivieri (ORCID: https://orcid.org/0000-0002-8465-3265)
- Giuseppe Rubens Pascucci (ORCID: https://orcid.org/0000-0002-5978-1193)
- Donato Amodio (ORCID: https://orcid.org/0000-0003-4550-3018)
- Chiara Pighi (ORCID: https://orcid.org/0000-0001-6163-0135)
- Chiara Medri
- Nicole Colantoni
- Ofer Levy (ORCID: https://orcid.org/0000-0002-5859-1945)
- Enrico Angelo Emili
- Nicola Cotugno (ORCID: https://orcid.org/0000-0002-7748-1581)
- Lorenza Putignani (ORCID: https://orcid.org/0000-0003-0134-2830)
- Paolo Rossi
- Marco Sanna
- Paolo Palma
Institutions
- Broad Institute (US)
- University of Rome Tor Vergata (IT)
- Boston Children's Hospital (US)
- Bambino Gesù Children's Hospital (IT)
Publication Details
- Journal
- Vaccine
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1016/j.vaccine.2025.126778
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- Ministero dell'Università e della Ricerca