Gold nanoparticles-supported iron oxide particles endows bone scaffolds with anti-tumor function
Iron oxide (Fe-O) has anti-tumor properties, due to its ability of catalyzing hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) of tumor cells to generate reactive oxygen species (ROS) and then cause ferroptosis. Its anti-tumor performance is restricted due to insufficient H<sub>2</sub>O<sub>2</sub> in tumor cells. A nanomedicine, Au nanoparticles (NPs) grown on Fe-O, was integrated into poly-l-lactide (PLLA) scaffolds. Results indicated that Au NPs could consume glucose of tumor cells to produce H<sub>2</sub>O<sub>2</sub>, which supplemented reaction substrate. PLLA/Au@Fe-O scaffold showed enhanced anti-tumor activities against MG63, including increased mortality, decreased migration and colony formation. PLLA/Au@Fe-O scaffold promoted ferroptosis in MG63, including up-regulation of COX-2 protein, down-regulation of FTH1 protein and GPX4 protein. PLLA/Au@Fe-O scaffold also promoted autophagy in MG63, including down-regulation of P62 protein, and up-regulation of LC3BII/I. Mechanistically, PLLA/Au@Fe-O scaffold possessed enhanced anti-tumor activities through promoting ferroptosis and autophagy.
Authors
- Tiantian He (ORCID: https://orcid.org/0000-0002-1604-3131)
- Shuping Peng (ORCID: https://orcid.org/0000-0003-3070-5135)
- Wenjing Yang (ORCID: https://orcid.org/0000-0003-1919-4848)
- Youwen Yang (ORCID: https://orcid.org/0000-0003-1557-0252)
- Cijun Shuai
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
- Jiangxi University of Science and Technology (CN)
Publication Details
- Journal
- Free Radical Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1080/10715762.2025.2466246
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China