Meningeal leukaemic aggregates as foci of cell expansion and chemoresistance in acute lymphoblastic leukaemia metastasis
Our results provide evidence for the formation of metastatic ALL-leptomeningeal cell aggregates, their pro-inflammatory profile and their contribution to leukaemic cell expansion, survival and chemoresistance in the CNS.
Authors
- Paula Ortiz-Sánchez
- Eva Jiménez (ORCID: https://orcid.org/0000-0003-0832-1602)
- Jaris Valencia (ORCID: https://orcid.org/0000-0002-3112-5944)
- Manuel R. Ramírez (ORCID: https://orcid.org/0000-0003-0332-6973)
- Lidia M. Fernández-Sevilla (ORCID: https://orcid.org/0000-0003-0076-3254)
- Rosa Sacedón (ORCID: https://orcid.org/0000-0002-7486-7120)
- Isabel Fariñas (ORCID: https://orcid.org/0000-0003-2903-4960)
- Ángeles Vicente (ORCID: https://orcid.org/0000-0002-9456-5541)
- Alberto Varas (ORCID: https://orcid.org/0000-0001-8329-6457)
- Sara González-Soto
- Luz H Villamizar
Institutions
- Universidad Complutense de Madrid (ES)
- Hospital Clínico San Carlos (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Hospital Universitario de La Princesa (ES)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1007/s13402-025-01043-y
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad Complutense de Madrid
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III