Host Response Stratification in Malarial and Non-malarial Sepsis: A Prospective, Multicenter Analysis From Uganda
Host responses are largely conserved in malarial and non-malarial sepsis but may be distinguished by a signature of relative immunosuppression in the former. Further investigations are needed to differentiate mechanisms of malarial and non-malarial sepsis, with the goal of informing pathogen-stratified and pathogen-agnostic treatment strategies.
Authors
- Kai Nie (ORCID: https://orcid.org/0000-0002-8253-9688)
- Joweria Nakaseegu (ORCID: https://orcid.org/0000-0001-9864-0679)
- Barnabas Bakamutumaho (ORCID: https://orcid.org/0000-0003-4259-8509)
- Misaki Wayengera (ORCID: https://orcid.org/0000-0001-7239-8079)
- John Kayiwa (ORCID: https://orcid.org/0000-0002-1840-1801)
- Jingjing Qi (ORCID: https://orcid.org/0000-0002-9368-1882)
- Matthew J. Cummings (ORCID: https://orcid.org/0000-0003-2906-0966)
- Jane Achan (ORCID: https://orcid.org/0000-0001-8111-025X)
- Alin S. Tomoiaga (ORCID: https://orcid.org/0000-0003-2221-8484)
- Julius J. Lutwama (ORCID: https://orcid.org/0000-0002-3210-722X)
- Pauline Byakika‐Kibwika (ORCID: https://orcid.org/0000-0003-0757-1968)
- Seunghee Kim‐Schulze (ORCID: https://orcid.org/0000-0003-0192-4400)
- Hui Xie (ORCID: https://orcid.org/0000-0002-3941-4150)
- Irene Nayiga
- Martina Cathy Nakibuuka
- Xiaohong Lu (ORCID: https://orcid.org/0000-0001-6417-0250)
- Moses Muwanga
- Nicholas Owor
- Stephen Kyebambe
- Max R. O’Donnell (ORCID: https://orcid.org/0000-0002-1232-3718)
- Xiaoyu Che (ORCID: https://orcid.org/0000-0003-0001-4122)
- Walter Ian Lipkin (ORCID: https://orcid.org/0000-0002-8768-9386)
- Steven J. Reynolds (ORCID: https://orcid.org/0000-0002-5403-2759)
- Joseph Shinyale
- Mercy Haumba
- Jesse Ross (ORCID: https://orcid.org/0009-0008-3405-0897)
- Thomas Ochar
- Christopher Nsereko
- Bryan Villagomez
- Sam Miake-Lye
Institutions
- National Institutes of Health (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Ministry of Agriculture, Animal Industry and Fisheries (UG)
- Ministry of Health (UG)
- Rakai Health Sciences Program (UG)
- National Institute of Allergy and Infectious Diseases (US)
- Makerere University (UG)
- Columbia University (US)
- Uganda Virus Research Institute (UG)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1097/ccm.0000000000006591
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00