Hydrazide-Hydrazone Derivatives and Their Antitubercular Activity
This review aims to evaluate the mechanisms of action of current and emerging anti-TB drugs and molecules, emphasizing hydrazone functionality. Hydrazone compounds, featuring an azomethine group (R1–HN–N=CR2R3), exhibit potent anti-TB and broad-spectrum anti-infective properties. It includes the synthesis and biological testing of hydrazide-hydrazones, with a focus on their anti-TB activities reported in the literature. It highlights promising candidates for future anti-TB therapies, underscoring hydrazones’ role as a crucial pharmacophore in drug design against tuberculosis and other infectious diseases. This review summarizes pivotal findings in the development of hydrazone-based compounds, contributing to the ongoing search for effective anti-infective agents.
Authors
- Suraj N. Mali (ORCID: https://orcid.org/0000-0003-1995-136X)
- Afzal B. Shaik (ORCID: https://orcid.org/0000-0002-9036-1963)
- Jorddy Neves Cruz (ORCID: https://orcid.org/0000-0003-0529-3714)
- Snehal Arvindekar (ORCID: https://orcid.org/0000-0001-6368-3038)
- Bapu R. Thorat (ORCID: https://orcid.org/0000-0003-4408-1319)
- Bontha Venkata Subrahmanya Lokesh (ORCID: https://orcid.org/0000-0002-3461-6781)
- Mozaniel Santana de Oliveira (ORCID: https://orcid.org/0000-0002-4076-2443)
- Umang Shah (ORCID: https://orcid.org/0000-0001-6748-2137)
- Akash Garg (ORCID: https://orcid.org/0000-0002-6127-7412)
- Ram K. Agrawal
Institutions
- Museu Paraense Emílio Goeldi (BR)
- Vignan's Foundation for Science, Technology & Research (IN)
- Rajiv Gandhi University of Health Sciences (IN)
- Charotar University of Science and Technology (IN)
- University of Malaya (MY)
- Universidade Federal do Amapá (BR)
- D.Y. Patil University (IN)
- Government Medical College (IN)
- Saveetha University (IN)
- Bharati Vidyapeeth (Deemed to be University) (IN)
Publication Details
- Journal
- Russian Journal of Bioorganic Chemistry
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1134/s1068162025010054
- Citations
- 3
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 2.81