Rack1 promotes breast cancer stemness properties and tumorigenesis through the E2F1-SOX2 axis
This study thus unveils a novel mechanism through which Rack1 executes its oncogenic function. This study also demonstrates that targeting the Rack1-E2F-SOX2 axis may be a potential strategy to inhibit breast cancer development and progression.
Authors
- Yanfei Jia (ORCID: https://orcid.org/0000-0002-0670-1604)
- Ruifang Niu (ORCID: https://orcid.org/0000-0002-8845-8838)
- Fei Zhang (ORCID: https://orcid.org/0000-0001-7434-7339)
- He Zhang (ORCID: https://orcid.org/0000-0001-9954-4451)
- Zhiyong Wang (ORCID: https://orcid.org/0000-0002-3574-6078)
- Yanfen Cui (ORCID: https://orcid.org/0000-0001-7522-3450)
- Wei Zhou (ORCID: https://orcid.org/0000-0002-3152-7898)
- Luoming Zhang (ORCID: https://orcid.org/0000-0002-9007-0947)
- Liming Liu (ORCID: https://orcid.org/0009-0003-1691-670X)
- Shuhua Chen
- Hui Guo
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1186/s12935-025-03678-1
- Citations
- 5
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China