A bacterial antiviral system detects and directly fights against infection
Bacteria have developed many strategies to defend themselves from phages — the viruses that infect them. The Zorya defence system uses a previously undescribed antiviral strategy. An inner-membrane-anchored complex detects phage infection, resulting in recruitment of enzymes inside the cell that digest incoming phage DNA, thereby rapidly preventing infection. Protein complex in bacterial cell membrane acts like a rotary motor to recruit DNA-degrading enzymes to defend against phage infection.
Publication Details
- Journal
- Nature
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1038/d41586-025-00416-5
- Citations
- 1
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.81