A bacterial antiviral system detects and directly fights against infection

Bacteria have developed many strategies to defend themselves from phages — the viruses that infect them. The Zorya defence system uses a previously undescribed antiviral strategy. An inner-membrane-anchored complex detects phage infection, resulting in recruitment of enzymes inside the cell that digest incoming phage DNA, thereby rapidly preventing infection. Protein complex in bacterial cell membrane acts like a rotary motor to recruit DNA-degrading enzymes to defend against phage infection.

Publication Details

Journal
Nature
Published
2025-02-12
DOI
https://doi.org/10.1038/d41586-025-00416-5
Citations
1
Primary Topic
CRISPR and Genetic Engineering
Type
article
Field-Weighted Citation Impact
0.81
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article

A bacterial antiviral system detects and directly fights against infection

1 citations
Nature
CRISPR and Genetic Engineering
0.81
article

A bacterial antiviral system detects and directly fights against infection

article en
1 citations

Abstract

Bacteria have developed many strategies to defend themselves from phages — the viruses that infect them. The Zorya defence system uses a previously undescribed antiviral strategy. An inner-membrane-anchored complex detects phage infection, resulting in recruitment of enzymes inside the cell that digest incoming phage DNA, thereby rapidly preventing infection. Protein complex in bacterial cell membrane acts like a rotary motor to recruit DNA-degrading enzymes to defend against phage infection.

Nature
Openalex Percentile: Top 31%
CRISPR and Genetic Engineering
0.81
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A bacterial antiviral system detects and directly fights against infection · Nature (2025) | TGRS Research Map | TGRS