<scp>HMGB1</scp> blood levels and neurological outcomes after traumatic brain injury: Insights from an exploratory study
This study examines how a protein called HMGB1 may contribute to epilepsy and cognitive deficits after traumatic brain injury (TBI). Patients with higher HMGB1 levels were more likely to develop epilepsy and experience significant cognitive decline within a year. Reducing HMGB1 and related inflammation was associated with better cognitive function and overall brain health. These findings suggest that HMGB1 could be a valuable marker and a potential target for treatments to prevent epilepsy and improve brain recovery after TBI.
Authors
- Devi Mohan (ORCID: https://orcid.org/0000-0002-0898-2729)
- Yu Mey Lee
- Ángel Aledo‐Serrano (ORCID: https://orcid.org/0000-0003-4889-3365)
- Jegan Thanabalan (ORCID: https://orcid.org/0000-0001-9790-7191)
- Irma Wati Ngadimon (ORCID: https://orcid.org/0000-0002-0914-8058)
- Wing Loong Cheong (ORCID: https://orcid.org/0000-0002-8652-7369)
- Ching Soong Khoo (ORCID: https://orcid.org/0000-0002-6756-0411)
- Hui Jan Tan (ORCID: https://orcid.org/0000-0003-4827-7984)
- Farizal Fadzil
- Mohd. Farooq Shaikh (ORCID: https://orcid.org/0000-0001-9865-6224)
- Alina Arulsamy
- Nor Syazwani Chamhuri
- Nursyazwana Zolkafli
Institutions
- Monash University Malaysia (MY)
- Charles Sturt University (AU)
- The University of Queensland (AU)
- Hospital Kuala Lumpur (MY)
- University of Malaya (MY)
- University of Oxford (GB)
- National University of Malaysia (MY)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1002/epi4.70001
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Monash University
- Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia